Blister meaning : A small bubble between the layers of the skin that contains watery or bloody fluid and is caused by friction and pressure, burning, freezing, chemical irritation, disease or infection. A swelling on a plant. Something applied to the skin to raise a blister; a vesicatory or other applied medicine. A bubble, as on a painted surface. (roofing) An enclosed pocket of air, which may be mixed with water or solvent vapor, trapped between impermeable layers of felt or between the membrane and substrate. A type of pre-formed packaging made from plastic that contains cavities. A cause of annoyance To raise blisters on. To have a blister form. To criticise severely. To break out in blisters.