Maddest meaning : Insane; crazy, mentally deranged. (chiefly US; informal in UK) Angry, annoyed. Bizarre; incredible. Wildly confused or excited. Extremely foolish or unwise; irrational; imprudent. (usually with for or about) Extremely enthusiastic about; crazy about; infatuated with; overcome with desire for. (of animals) Abnormally ferocious or furious; or, rabid, affected with rabies. (chiefly Northeastern US) Intensifier, signifies an abundance or high quality of a thing; very, much or many. (of a compass needle) Having impaired polarity.