Mess meaning : A disagreeable mixture or confusion of things; hence, a situation resulting from blundering or from misunderstanding; disorder. A large quantity or number. Excrement. A person in a state of (especially emotional) turmoil or disarray; an emotional wreck. (transitive, often used with "up") To make untidy or dirty. (transitive, often used with "up") To throw into disorder or to ruin. To interfere. (used with "with") To screw around with, to bother, to be annoying to.