Tweaks meaning : A sharp pinch or jerk; a twist or twitch. A slight adjustment or modification. Trouble; distress; tweag. A prostitute. An additional input to a block cipher, used in conjunction with the key to select the permutation computed by the cipher. To pinch and pull with a sudden jerk and twist; to twitch. To adjust slightly; to fine-tune. To twit or tease. To abuse methamphetamines, especially crystal meth. To exhibit symptoms of methamphetamine abuse, such as extreme nervousness, compulsiveness, erratic motion, excitability; possibly a blend of twitch and freak. To exhibit extreme nervousness, evasiveness when confronted by law enforcement or other authority (e.g., customs agents, border patrol, teacher, etc.), mimicking methamphetamine abuse symptoms.