Ghetto meaning : An (often walled) area of a city in which Jews are concentrated by force and law. (Used particularly of areas in medieval Italy and in Nazi-controlled Europe.) An (often impoverished) area of a city inhabited predominantly by members of a specific nationality, ethnicity or race. An area in which people who are distinguished by sharing something other than ethnicity concentrate or are concentrated. (sometimes derogatory) An isolated, self-contained, segregated subsection, area or field of interest; often of minority or specialist interest. To confine (a specified group of people) to a ghetto. Of or relating to a ghetto or to ghettos in general. Unseemly and indecorous or of low quality; cheap; shabby, crude. Characteristic of the style, speech, or behavior of residents of a predominantly black or other ghetto in the United States. Having been raised in a ghetto in the United States.