Oof meaning : A sound made in pain, as when expelling air after being struck. A sound mimicking the loss of air, as if someone's solar plexus had just been struck. An expression of one's own physical pain. An expression in sympathy at another's pain. A reply to an insult seen as savage (frequently one that is tongue-in-cheek or joking). An expression of disappointment. Expressing surprise at the high price of something.