Twiddle meaning : A slight twist with the fingers. A pimple. A small decorative embellishment. A small musical flourish. A tilde. A drawn line that is curvy or twisted. A tiny bit A tizzy To wiggle, fidget or play with; to move around. To flip or switch two adjacent bits (binary digits). To be in an equivalence relation with. To play with anything; hence, to be busy about trifles.